Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Δ murine hearts modelling long QT syndrome 3

Long QT(3) (LQT3) syndrome is associated with incomplete Na(+) channel inactivation, abnormal repolarization kinetics and prolonged cardiac action potential duration (APD). Electrophysiological effects of flecainide and quinidine were compared in Langendorff-perfused wild-type (WT), and genetically...

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Main Authors: Stokoe, Kate S, Thomas, Glyn, Goddard, Catharine A, Colledge, William H, Grace, Andrew A, Huang, Christopher L-H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810389/
https://ncbi.nlm.nih.gov/pubmed/17023504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.117945
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