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Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer

BACKGROUND: Urodele amphibians like the axolotl are unique among vertebrates in their ability to regenerate and their resistance to develop cancers. It is unknown whether these traits are linked at the molecular level. RESULTS: Blocking p53 signaling in axolotls using the p53 inhibitor, pifithrin-α,...

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主要な著者: Villiard, Éric, Brinkmann, Henner, Moiseeva, Olga, Mallette, Frédérick A, Ferbeyre, Gerardo, Roy, Stéphane
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072957/
https://ncbi.nlm.nih.gov/pubmed/17903248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-7-180
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