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Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor

The mechanism by which the androgen receptor (AR) distinguishes between agonist and antagonist ligands is poorly understood. AR antagonists are currently used to treat prostate cancer. However, mutations commonly develop in patients that convert these compounds to agonists. Recently, our laboratory...

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Detalles Bibliográficos
Main Authors: Bohl, Casey E., Miller, Duane D., Chen, Jiyun, Bell, Charles E., Dalton, James T.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072880/
https://ncbi.nlm.nih.gov/pubmed/16129672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M507464200
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