An AICD-based functional screen to identify APP metabolism regulators

BACKGROUND: A central event in Alzheimer's disease (AD) is the regulated intramembraneous proteolysis of the β-amyloid precursor protein (APP), to generate the β-amyloid (Aβ) peptide and the APP intracellular domain (AICD). Aβ is the major component of amyloid plaques and AICD displays transcri...

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Autori principali: Zhang, Can, Khandelwal, Preeti J, Chakraborty, Ranjita, Cuellar, Trinna L, Sarangi, Srikant, Patel, Shyam A, Cosentino, Christopher P, O'Connor, Michael, Lee, Jeremy C, Tanzi, Rudolph E, Saunders, Aleister J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central|1 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2071909/
https://ncbi.nlm.nih.gov/pubmed/17718916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-15
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