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FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type.

FK-506-binding proteins (FKBPs), which in T cells are supposed to mediate the immunosuppressive effects of the compounds FK-506 and rapamycin, have been isolated from Streptomyces chrysomallus, S. hygroscopicus subsp. ascomyceticus, and S. hygroscopicus. The latter two strains are producers of ascom...

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Bibliografiske detaljer
Main Authors: Pahl, A, Keller, U
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC207125/
https://ncbi.nlm.nih.gov/pubmed/1381710
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