Regulation of Cdc2/Cyclin B Activation in Xenopus Egg Extracts via Inhibitory Phosphorylation of Cdc25C Phosphatase by Ca(2+)/Calmodium-dependent Kinase II

Activation of Cdc2/cyclin B kinase and entry into mitosis requires dephosphorylation of inhibitory sites on Cdc2 by Cdc25 phosphatase. In vertebrates, Cdc25C is inhibited by phosphorylation at a single site targeted by the checkpoint kinases Chk1 and Cds1/Chk2 in response to DNA damage or replicatio...

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Detalhes bibliográficos

Publicado no:	Mol Biol Cell
Principais autores:	Hutchins, James R. A., Dikovskaya, Dina, Clarke, Paul R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Cell Biology 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC206995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14517314/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-02-0061
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