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Regulation of Cdc2/Cyclin B Activation in Xenopus Egg Extracts via Inhibitory Phosphorylation of Cdc25C Phosphatase by Ca(2+)/Calmodium-dependent Kinase II

Activation of Cdc2/cyclin B kinase and entry into mitosis requires dephosphorylation of inhibitory sites on Cdc2 by Cdc25 phosphatase. In vertebrates, Cdc25C is inhibited by phosphorylation at a single site targeted by the checkpoint kinases Chk1 and Cds1/Chk2 in response to DNA damage or replicatio...

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Udgivet i:Mol Biol Cell
Principais autores: Hutchins, James R. A., Dikovskaya, Dina, Clarke, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2003
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC206995/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14517314/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-02-0061
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