Azetidinones as Vasopressin V1a Antagonists

The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC(50) 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing hormone receptor. Structure-activity relationships for...

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Détails bibliographiques
Auteurs principaux: Guillon, Christophe D., Koppel, Gary A., Brownstein, Michael J., Chaney, Michael O., Ferris, Craig F., Lu, Shi-fang, Fabio, Karine M., Miller, Marvin J., Heindel, Ned D., Hunden, David C., Cooper, Robin D. G., Kaldor, Stephen W., Skelton, Jeffrey J., Dressman, Bruce A., Clay, Michael P., Steinberg, Mitchell I., Bruns, Robert F., Simon, Neal G.
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2067992/
https://ncbi.nlm.nih.gov/pubmed/17234419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.12.031
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