Azetidinones as Vasopressin V1a Antagonists

The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC(50) 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing hormone receptor. Structure-activity relationships for...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Guillon, Christophe D., Koppel, Gary A., Brownstein, Michael J., Chaney, Michael O., Ferris, Craig F., Lu, Shi-fang, Fabio, Karine M., Miller, Marvin J., Heindel, Ned D., Hunden, David C., Cooper, Robin D. G., Kaldor, Stephen W., Skelton, Jeffrey J., Dressman, Bruce A., Clay, Michael P., Steinberg, Mitchell I., Bruns, Robert F., Simon, Neal G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2067992/
https://ncbi.nlm.nih.gov/pubmed/17234419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.12.031
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge