Azetidinones as Vasopressin V1a Antagonists

The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC(50) 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing hormone receptor. Structure-activity relationships for...

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Detalhes bibliográficos
Main Authors: Guillon, Christophe D., Koppel, Gary A., Brownstein, Michael J., Chaney, Michael O., Ferris, Craig F., Lu, Shi-fang, Fabio, Karine M., Miller, Marvin J., Heindel, Ned D., Hunden, David C., Cooper, Robin D. G., Kaldor, Stephen W., Skelton, Jeffrey J., Dressman, Bruce A., Clay, Michael P., Steinberg, Mitchell I., Bruns, Robert F., Simon, Neal G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2067992/
https://ncbi.nlm.nih.gov/pubmed/17234419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.12.031
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