Azetidinones as Vasopressin V1a Antagonists

The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC(50) 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing hormone receptor. Structure-activity relationships for...

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Detaylı Bibliyografya
Asıl Yazarlar: Guillon, Christophe D., Koppel, Gary A., Brownstein, Michael J., Chaney, Michael O., Ferris, Craig F., Lu, Shi-fang, Fabio, Karine M., Miller, Marvin J., Heindel, Ned D., Hunden, David C., Cooper, Robin D. G., Kaldor, Stephen W., Skelton, Jeffrey J., Dressman, Bruce A., Clay, Michael P., Steinberg, Mitchell I., Bruns, Robert F., Simon, Neal G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2067992/
https://ncbi.nlm.nih.gov/pubmed/17234419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.12.031
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