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DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction

DNA methylation has been implicated in chromatin condensation and nuclear organization, especially at sites of constitutive heterochromatin. How this is mediated has not been clear. In this study, using mutant mouse embryonic stem cells completely lacking in DNA methylation, we show that DNA methyla...

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Bibliografske podrobnosti
Main Authors: Gilbert, Nick, Thomson, Inga, Boyle, Shelagh, Allan, James, Ramsahoye, Bernard, Bickmore, Wendy A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064831/
https://ncbi.nlm.nih.gov/pubmed/17485486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200607133
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