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Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells

During differentiation thousands of genes are repositioned toward or away from the nuclear envelope. These movements correlate with changes in transcription and replication timing. Here, using synthetic transcription factors (TALE-TFs) we show that transcriptional activation of endogenous genes by a...

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Publicado en:Science
Autores principales: Therizols, Pierre, Illingworth, Robert S., Courilleau, Celine, Boyle, Shelagh, Wood, Andrew J., Bickmore, Wendy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529354/
https://ncbi.nlm.nih.gov/pubmed/25477464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1259587
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