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Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells

During differentiation thousands of genes are repositioned toward or away from the nuclear envelope. These movements correlate with changes in transcription and replication timing. Here, using synthetic transcription factors (TALE-TFs) we show that transcriptional activation of endogenous genes by a...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Therizols, Pierre, Illingworth, Robert S., Courilleau, Celine, Boyle, Shelagh, Wood, Andrew J., Bickmore, Wendy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529354/
https://ncbi.nlm.nih.gov/pubmed/25477464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1259587
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