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Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer

BACKGROUND: Epigenetic changes are being increasingly recognized as a prominent feature of cancer. This occurs not only at individual genes, but also over larger chromosomal domains. To investigate this, we set out to identify large chromosomal domains of epigenetic dysregulation in breast cancers....

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Rafique, Sehrish, Thomas, Jeremy S., Sproul, Duncan, Bickmore, Wendy A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536608/
https://ncbi.nlm.nih.gov/pubmed/26235388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0719-9
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