Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind directly to p-STAT5A and are required to promote its nuclear translocation. Using permeabilized cells, w...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Kawashima, Toshiyuki, Bao, Ying Chun, Nomura, Yasushi, Moon, Yuseok, Tonozuka, Yukio, Minoshima, Yukinori, Hatori, Tomonori, Tsuchiya, Akiho, Kiyono, Mari, Nosaka, Tetsuya, Nakajima, Hideaki, Williams, David A., Kitamura, Toshio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2006
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064703/
https://ncbi.nlm.nih.gov/pubmed/17178910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200604073
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