A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors

In addition to their pleiotropic functions under physiological conditions, transcription factors STAT3 and STAT5 also have oncogenic activities, but how activated STATs are transported to the nucleus has not been fully understood. Here we show that an MgcRacGAP mutant lacking its nuclear localizing...

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Autori principali: Kawashima, Toshiyuki, Bao, Ying Chun, Minoshima, Yukinori, Nomura, Yasushi, Hatori, Tomonori, Hori, Tetsuya, Fukagawa, Tatsuo, Fukada, Toshiyuki, Takahashi, Noriko, Nosaka, Tetsuya, Inoue, Makoto, Sato, Tomohiro, Kukimoto-Niino, Mutsuko, Shirouzu, Mikako, Yokoyama, Shigeyuki, Kitamura, Toshio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655612/
https://ncbi.nlm.nih.gov/pubmed/19158271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01423-08
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