Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind directly to p-STAT5A and are required to promote its nuclear translocation. Using permeabilized cells, w...

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Hlavní autoři: Kawashima, Toshiyuki, Bao, Ying Chun, Nomura, Yasushi, Moon, Yuseok, Tonozuka, Yukio, Minoshima, Yukinori, Hatori, Tomonori, Tsuchiya, Akiho, Kiyono, Mari, Nosaka, Tetsuya, Nakajima, Hideaki, Williams, David A., Kitamura, Toshio
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2006
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064703/
https://ncbi.nlm.nih.gov/pubmed/17178910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200604073
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