Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind directly to p-STAT5A and are required to promote its nuclear translocation. Using permeabilized cells, w...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Kawashima, Toshiyuki, Bao, Ying Chun, Nomura, Yasushi, Moon, Yuseok, Tonozuka, Yukio, Minoshima, Yukinori, Hatori, Tomonori, Tsuchiya, Akiho, Kiyono, Mari, Nosaka, Tetsuya, Nakajima, Hideaki, Williams, David A., Kitamura, Toshio
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2006
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064703/
https://ncbi.nlm.nih.gov/pubmed/17178910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200604073
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items