Inhibition of Rho A activity causes pemphigus skin blistering

The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence that PV–immunoglobulin G (IgG) and PF-IgG induce skin blistering by interference with Rho A signaling. In...

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Detalhes bibliográficos
Main Authors: Waschke, Jens, Spindler, Volker, Bruggeman, Paola, Zillikens, Detlef, Schmidt, Gudula, Drenckhahn, Detlev
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064672/
https://ncbi.nlm.nih.gov/pubmed/17130286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200605125
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