Inhibition of Rho A activity causes pemphigus skin blistering

The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence that PV–immunoglobulin G (IgG) and PF-IgG induce skin blistering by interference with Rho A signaling. In...

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Dades bibliogràfiques
Autors principals: Waschke, Jens, Spindler, Volker, Bruggeman, Paola, Zillikens, Detlef, Schmidt, Gudula, Drenckhahn, Detlev
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064672/
https://ncbi.nlm.nih.gov/pubmed/17130286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200605125
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