Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies

In mammals, nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that degrades mRNA harboring a premature termination codon to prevent the synthesis of truncated proteins. To gain insight into the NMD mechanism, we identified NMD inhibitor 1 (NMDI 1) as a small molecule inhibitor of the...

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Hlavní autoři: Durand, Sébastien, Cougot, Nicolas, Mahuteau-Betzer, Florence, Nguyen, Chi-Hung, Grierson, David S., Bertrand, Edouard, Tazi, Jamal, Lejeune, Fabrice
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2007
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064650/
https://ncbi.nlm.nih.gov/pubmed/17893241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200611086
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