Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination

LAPTM5 is a lysosomal transmembrane protein expressed in immune cells. We show that LAPTM5 binds the ubiquitin-ligase Nedd4 and GGA3 to promote LAPTM5 sorting from the Golgi to the lysosome, an event that is independent of LAPTM5 ubiquitination. LAPTM5 contains three PY motifs (L/PPxY), which bind N...

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Bibliographic Details
Main Authors: Pak, Youngshil, Glowacka, Wioletta K., Bruce, M. Christine, Pham, Nam, Rotin, Daniela
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2006
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064599/
https://ncbi.nlm.nih.gov/pubmed/17116753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200603001
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