Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein involved in the DNA damage response. AOA2 cells are...

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Auteurs principaux: Suraweera, Amila, Becherel, Olivier J., Chen, Philip, Rundle, Natalie, Woods, Rick, Nakamura, Jun, Gatei, Magtouf, Criscuolo, Chiara, Filla, Alessandro, Chessa, Luciana, Fußer, Markus, Epe, Bernd, Gueven, Nuri, Lavin, Martin F.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2007
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064358/
https://ncbi.nlm.nih.gov/pubmed/17562789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200701042
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