Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein involved in the DNA damage response. AOA2 cells are...

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Detalhes bibliográficos
Main Authors: Suraweera, Amila, Becherel, Olivier J., Chen, Philip, Rundle, Natalie, Woods, Rick, Nakamura, Jun, Gatei, Magtouf, Criscuolo, Chiara, Filla, Alessandro, Chessa, Luciana, Fußer, Markus, Epe, Bernd, Gueven, Nuri, Lavin, Martin F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064358/
https://ncbi.nlm.nih.gov/pubmed/17562789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200701042
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