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A disease- and phosphorylation-related nonmechanical function for keratin 8
Keratin 8 (K8) variants predispose to human liver injury via poorly understood mechanisms. We generated transgenic mice that overexpress the human disease-associated K8 Gly61-to-Cys (G61C) variant and showed that G61C predisposes to liver injury and apoptosis and dramatically inhibits K8 phosphoryla...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064169/ https://ncbi.nlm.nih.gov/pubmed/16818723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200602146 |
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