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A disease- and phosphorylation-related nonmechanical function for keratin 8

Keratin 8 (K8) variants predispose to human liver injury via poorly understood mechanisms. We generated transgenic mice that overexpress the human disease-associated K8 Gly61-to-Cys (G61C) variant and showed that G61C predisposes to liver injury and apoptosis and dramatically inhibits K8 phosphoryla...

詳細記述

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書誌詳細
主要な著者: Ku, Nam-On, Omary, M. Bishr
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064169/
https://ncbi.nlm.nih.gov/pubmed/16818723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200602146
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