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Synthesis, biological evaluation and molecular modeling studies of N(6)-benzyladenosine analogues as potential anti-toxoplasma agents
Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and depends on salvage pathways for its purine requirements. Adenosine kinase (EC.2.7.1.20) is the major enzyme in the salvage of purines in these pa...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064036/ https://ncbi.nlm.nih.gov/pubmed/17306769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.01.026 |
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