Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii
The purine nucleoside analogue NBMPR {nitrobenzylthioinosine or 6-[(4-nitrobenzyl)thio]-9-β-d-ribofuranosylpurine} was selectively phosphorylated to its nucleoside 5′-monophosphate by Toxoplasma gondii but not mammalian adenosine kinase (EC 2.7.1.20). NBMPR was also cleaved in toxoplasma to its nucl...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89497/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508021/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2437 |
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