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Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii

The purine nucleoside analogue NBMPR {nitrobenzylthioinosine or 6-[(4-nitrobenzyl)thio]-9-β-d-ribofuranosylpurine} was selectively phosphorylated to its nucleoside 5′-monophosphate by Toxoplasma gondii but not mammalian adenosine kinase (EC 2.7.1.20). NBMPR was also cleaved in toxoplasma to its nucl...

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Detalhes bibliográficos
Main Authors: el Kouni, Mahmoud H., Guarcello, Vincenzo, Al Safarjalani, Omar N., Naguib, Fardos N. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89497/
https://ncbi.nlm.nih.gov/pubmed/10508021
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