Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii

The purine nucleoside analogue NBMPR {nitrobenzylthioinosine or 6-[(4-nitrobenzyl)thio]-9-β-d-ribofuranosylpurine} was selectively phosphorylated to its nucleoside 5′-monophosphate by Toxoplasma gondii but not mammalian adenosine kinase (EC 2.7.1.20). NBMPR was also cleaved in toxoplasma to its nucl...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	el Kouni, Mahmoud H., Guarcello, Vincenzo, Al Safarjalani, Omar N., Naguib, Fardos N. M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89497/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508021/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2437
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