7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities

Toxoplasma gondii adenosine kinase (EC.2.7.1.20) is the major route of adenosine metabolism in this parasite. The enzyme is significantly more active than any other enzyme of the purine salvage in T. gondii and has been established as a potential chemotherapeutic target for the treatment of toxoplas...

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Библиографические подробности
Главные авторы: Al Safarjalani, Omar N., Rais, Reem H., Kim, Young Ah, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581922/
https://ncbi.nlm.nih.gov/pubmed/18755159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.07.035
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