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DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells
DNA methylation plays a central role in the epigenetic regulation of gene expression in vertebrates. Genetic and biochemical data indicated that DNA methyltransferase 1 (Dnmt1) is indispensable for the maintenance of DNA methylation patterns in mice, but targeting of the DNMT1 locus in human HCT116...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064015/ https://ncbi.nlm.nih.gov/pubmed/17312023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610062 |
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