DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

DNA methylation plays a central role in the epigenetic regulation of gene expression in vertebrates. Genetic and biochemical data indicated that DNA methyltransferase 1 (Dnmt1) is indispensable for the maintenance of DNA methylation patterns in mice, but targeting of the DNMT1 locus in human HCT116...

Full description

Saved in:
Bibliographic Details
Main Authors: Spada, Fabio, Haemmer, Andrea, Kuch, David, Rothbauer, Ulrich, Schermelleh, Lothar, Kremmer, Elisabeth, Carell, Thomas, Längst, Gernot, Leonhardt, Heinrich
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064015/
https://ncbi.nlm.nih.gov/pubmed/17312023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610062
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items