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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
Conditional mouse models of polyglutamine diseases, such as Huntington's disease (HD), have revealed that cells can clear accumulated pathogenic proteins if the continuous production of the mutant transgene is halted. Invariably, the clearance of the protein leads to regression of the disease s...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063704/ https://ncbi.nlm.nih.gov/pubmed/16505167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200510065 |
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