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Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

The accumulation of ubiquitin-positive protein aggregates has been implicated in the pathogenesis of neurodegenerative diseases, heart disease and diabetes. Emerging evidence indicates that the autophagy lysosomal pathway plays a critical role in the clearance of ubiquitin aggregates, a process that...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Fan, Weiliang, Tang, Zaiming, Chen, Dandan, Moughon, Diana, Ding, Xiaojun, Chen, She, Zhu, Muyuan, Zhong, Qing
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423623/
https://ncbi.nlm.nih.gov/pubmed/20495340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.6.5.12189
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