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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

Conditional mouse models of polyglutamine diseases, such as Huntington's disease (HD), have revealed that cells can clear accumulated pathogenic proteins if the continuous production of the mutant transgene is halted. Invariably, the clearance of the protein leads to regression of the disease s...

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Bibliografske podrobnosti
Main Authors: Yamamoto, Ai, Cremona, M. Laura, Rothman, James E.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063704/
https://ncbi.nlm.nih.gov/pubmed/16505167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200510065
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