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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

Conditional mouse models of polyglutamine diseases, such as Huntington's disease (HD), have revealed that cells can clear accumulated pathogenic proteins if the continuous production of the mutant transgene is halted. Invariably, the clearance of the protein leads to regression of the disease s...

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書目詳細資料
Main Authors: Yamamoto, Ai, Cremona, M. Laura, Rothman, James E.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063704/
https://ncbi.nlm.nih.gov/pubmed/16505167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200510065
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