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The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
Akt kinases mediate cell growth and survival. Here, we report that a pro-apoptotic kinase, Mst1/STK4, is a physiological Akt1 interaction partner. Mst1 was identified as a component of an Akt1 multiprotein complex isolated from lipid raft-enriched fractions of LNCaP human prostate cancer cells. Endo...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063482/ https://ncbi.nlm.nih.gov/pubmed/17932490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601872 |
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