The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1

Akt kinases mediate cell growth and survival. Here, we report that a pro-apoptotic kinase, Mst1/STK4, is a physiological Akt1 interaction partner. Mst1 was identified as a component of an Akt1 multiprotein complex isolated from lipid raft-enriched fractions of LNCaP human prostate cancer cells. Endo...

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Main Authors: Cinar, Bekir, Fang, Ping-Ke, Lutchman, Mohini, Di Vizio, Dolores, Adam, Rosalyn M, Pavlova, Natalya, Rubin, Mark A, Yelick, Pamela C, Freeman, Michael R
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063482/
https://ncbi.nlm.nih.gov/pubmed/17932490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601872
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