Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

NUP98-HOXD13 (NHD13) fusions have been identified in patients with myelodysplastic syndrome (MDS), acute myelogenous leukemia (AML) and chronic myeloid leukemia blast crisis (CML-BC). We generated “knock-in” mouse embryonic stem (ES) cells that express a NHD13 fusion gene from the endogenous murine...

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Hauptverfasser: Slape, Christopher, Chung, Yang Jo, Soloway, Paul D., Tessarollo, Lino, Aplan, Peter D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063470/
https://ncbi.nlm.nih.gov/pubmed/17377591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.leu.2404648
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