Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy.

The increasing interest in 5-fluorouracil (5-FU) modulation and the development of new antifolates has focused attention in recent studies on the expression of the target enzyme thymidylate synthase (TS) as a determinant of drug sensitivity and resistance. Resistance to TS-directed drugs has been sh...

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Bibliographic Details
Main Authors: Findlay, M. P., Cunningham, D., Morgan, G., Clinton, S., Hardcastle, A., Aherne, G. W.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group|1 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063401/
https://ncbi.nlm.nih.gov/pubmed/9062414
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