Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

The viral reverse transcriptase (RT) provides an attractive target in the search for anti-HIV therapies. The nonnucleoside inhibitors (NNIs) are a diverse set of compounds (usually HIV-1 specific) that function by distorting the polymerase active site upon binding in a nearby pocket. Despite being p...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Esnouf, Robert M., Ren, Jingshan, Hopkins, Andrew L., Ross, Carl K., Jones, E. Yvonne, Stammers, David K., Stuart, David I.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3984
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