(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.

Ítems similars

• A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.
  per: Dueweke, T J, et al.
  Publicat: (1993)
• Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor
  per: Esnouf, Robert M., et al.
  Publicat: (1997)
• Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors
  per: Spence, Rebecca A., et al.
  Publicat: (1995)
• The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors
  per: Sluis-Cremer, Nicolas
  Publicat: (2014)
• Replicative Fitness Costs of Nonnucleoside Reverse Transcriptase Inhibitor Drug Resistance Mutations on HIV Subtype C
  per: Armstrong, Kimberly L., et al.
  Publicat: (2011)