(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.

The (alkylamino)piperidine bis(heteroaryl)piperizines (AAP-BHAPs) are a new class of human immunodeficiency virus type 1 (HIV-1)-specific inhibitors which were identified by targeted screening of recombinant reverse transcriptase (RT) enzymes carrying key nonnucleoside reverse transcriptase inhibito...

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Autores principales: Olmsted, R A, Slade, D E, Kopta, L A, Poppe, S M, Poel, T J, Newport, S W, Rank, K B, Biles, C, Morge, R A, Dueweke, T J, Yagi, Y, Romero, D L, Thomas, R C, Sharma, S K, Tarpley, W G
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC190245/
https://ncbi.nlm.nih.gov/pubmed/8648704
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