The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products

BACKGROUND AND PURPOSE: Licofelone is a dual inhibitor of the cyclooxygenase and 5-lipoxygenase (5-LO) pathway, and has been developed for the treatment of inflammatory diseases. Here, we investigated the molecular mechanisms underlying the inhibition by licofelone of the formation of 5-LO products....

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Hlavní autoři: Fischer, L, Hornig, M, Pergola, C, Meindl, N, Franke, L, Tanrikulu, Y, Dodt, G, Schneider, G, Steinhilber, D, Werz, O
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2050828/
https://ncbi.nlm.nih.gov/pubmed/17704828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707416
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