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New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues
BACKGROUND AND PURPOSE: The human prostacyclin receptor (hIP), a G-protein coupled receptor (GPCR) expressed mainly on platelets and vascular smooth muscle cells, plays important protective roles in the cardiovascular system. We hypothesized that significant insights could be gained into the structu...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2050826/ https://ncbi.nlm.nih.gov/pubmed/17704830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707413 |
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