New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues

BACKGROUND AND PURPOSE: The human prostacyclin receptor (hIP), a G-protein coupled receptor (GPCR) expressed mainly on platelets and vascular smooth muscle cells, plays important protective roles in the cardiovascular system. We hypothesized that significant insights could be gained into the structu...

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Bibliografiske detaljer
Main Authors: Stitham, J, Arehart, E, Gleim, S R, Li, N, Douville, K, Hwa, J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2050826/
https://ncbi.nlm.nih.gov/pubmed/17704830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707413
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