“Negative Vaccination” by Specific CD4(+) T Cell Tolerisation Enhances Virus-Specific Protective Antibody Responses

BACKGROUND: Cooperation of CD4(+) T helper cells with specific B cells is crucial for protective vaccination against pathogens by inducing long-lived neutralizing antibody responses. During infection with persistence-prone viruses, prolonged virus replication correlates with low neutralizing antibod...

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Detalhes bibliográficos
Main Authors: Lang, Karl S., Hegazy, Ahmed N., Lang, Philipp A., Eschli, Bruno, Löhning, Max, Hengartner, Hans, Zinkernagel, Rolf M., Recher, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2048666/
https://ncbi.nlm.nih.gov/pubmed/18000535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001162
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