Functional CD8(+) but not CD4(+) T cell responses develop independent of thymic epithelial MHC

The role of nonthymic epithelial (non-TE) MHC in T cell repertoire selection remains controversial. To analyze the relative roles of thymic epithelial (TE) and non-TE MHC in T cell repertoire selection, we have generated tetraparental aggregation chimeras (B6-nude↔BALB/c and B6↔BALB/c-nude) harborin...

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Hlavní autoři: Martinic, Marianne M., van den Broek, Maries F., Rülicke, Thomas, Huber, Christoph, Odermatt, Bernhard, Reith, Walter, Horvath, Edit, Zellweger, Raphael, Fink, Katja, Recher, Mike, Eschli, Bruno, Hengartner, Hans, Zinkernagel, Rolf M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599980/
https://ncbi.nlm.nih.gov/pubmed/16983067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606707103
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