Functional CD8(+) but not CD4(+) T cell responses develop independent of thymic epithelial MHC

The role of nonthymic epithelial (non-TE) MHC in T cell repertoire selection remains controversial. To analyze the relative roles of thymic epithelial (TE) and non-TE MHC in T cell repertoire selection, we have generated tetraparental aggregation chimeras (B6-nude↔BALB/c and B6↔BALB/c-nude) harborin...

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Detalhes bibliográficos
Main Authors: Martinic, Marianne M., van den Broek, Maries F., Rülicke, Thomas, Huber, Christoph, Odermatt, Bernhard, Reith, Walter, Horvath, Edit, Zellweger, Raphael, Fink, Katja, Recher, Mike, Eschli, Bruno, Hengartner, Hans, Zinkernagel, Rolf M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599980/
https://ncbi.nlm.nih.gov/pubmed/16983067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606707103
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