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Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination
AIMS: To identify the human cytochrome P450 (CYP) enzymes responsible for the formation of the 6β-hydroxy (6β-OHGz), 7β-hydroxy (7β-OHGz) and hydroxymethyl (MeOH-Gz) metabolites of gliclizide (Gz). METHODS: 6β-OHGz, 7β-OHGz and MeOH-Gz formation by human liver microsomes and a panel of recombinant h...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Publishing Ltd
2007
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2048545/ https://ncbi.nlm.nih.gov/pubmed/17517049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02943.x |
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