Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination

AIMS: To identify the human cytochrome P450 (CYP) enzymes responsible for the formation of the 6β-hydroxy (6β-OHGz), 7β-hydroxy (7β-OHGz) and hydroxymethyl (MeOH-Gz) metabolites of gliclizide (Gz). METHODS: 6β-OHGz, 7β-OHGz and MeOH-Gz formation by human liver microsomes and a panel of recombinant h...

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Hlavní autoři: Elliot, David J, Suharjono, Lewis, Benjamin C, Gillam, Elizabeth M J, Birkett, Donald J, Gross, Annette S, Miners, John O
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2007
Témata:
Drug Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2048545/
https://ncbi.nlm.nih.gov/pubmed/17517049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02943.x
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