An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid

AIMS: To characterize potential mechanism-based inactivation (MBI) of major human drug-metabolizing cytochromes P450 (CYP) by monoamine oxidase (MAO) inhibitors, including the antitubercular drug isoniazid. METHODS: Human liver microsomal CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A activities were inv...

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Bibliographic Details
Main Authors: Polasek, Thomas M, Elliot, David J, Somogyi, Andrew A, Gillam, Elizabeth M J, Lewis, Benjamin C, Miners, John O
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2006
Subjects:
Drug Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885050/
https://ncbi.nlm.nih.gov/pubmed/16669850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02627.x
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