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Requirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS Ribozyme

The glmS ribozyme is a catalytic RNA that self-cleaves at its 5′-end in the presence of glucosamine-6-phosphate (GlcN6P). We present structures of the glmS ribozyme from Thermoanaerobacter tengcongensis that are bound with the cofactor GlcN6P or the inhibitor glucose-6-phosphate (Glc6P) at 1.7 Å and...

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Autors principals: Klein, Daniel J., Wilkinson, Sara R., Been, Michael D., Ferré-D'Amaré, Adrian R.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2048488/
https://ncbi.nlm.nih.gov/pubmed/17804015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.07.062
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