West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis

West Nile virus (WNV)-mediated neuronal death is a hallmark of WNV meningitis and encephalitis. However, the mechanisms of WNV-induced neuronal damage are not well understood. We investigated WNV neuropathogenesis by using human neuroblastoma cells and primary rat hippocampal neurons. We observed th...

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Main Authors: Medigeshi, Guruprasad R., Lancaster, Alissa M., Hirsch, Alec J., Briese, Thomas, Lipkin, W. Ian, DeFilippis, Victor, Früh, Klaus, Mason, Peter W., Nikolich-Zugich, Janko, Nelson, Jay A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Cellular Response to Infection
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045561/
https://ncbi.nlm.nih.gov/pubmed/17686866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01151-07
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