Replication-Competent Herpes Simplex Virus 1 Isolates Selected from Cells Transfected with a Bacterial Artificial Chromosome DNA Lacking Only the U(L)49 Gene Vary with Respect to the Defect in the U(L)41 Gene Encoding Host Shutoff RNase

To generate a null U(L)49 gene mutant of herpes simplex virus 1 (HSV-1), we deleted from the viral DNA, encoded as a bacterial artificial chromosome (BAC), the U(L)49 open reading frame and, in a second step, restored it. Upon transfection into Vero cells, the BAC-ΔU(L)49 DNA yielded foci of degener...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sciortino, Maria Teresa, Taddeo, Brunella, Giuffrè-Cuculletto, Maria, Medici, Maria Antonietta, Mastino, Antonio, Roizman, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045545/
https://ncbi.nlm.nih.gov/pubmed/17670820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01239-07
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados