Molecular Profiling of Ovine Prion Diseases by Using Thermolysin-Resistant PrP(Sc) and Endogenous C2 PrP Fragments

Disease-associated PrP fragments produced upon in vitro or in vivo proteolysis can provide significant insight into the causal strain of prion disease. Here we describe a novel molecular strain typing assay that used thermolysin digestion of caudal medulla samples to produce PrP(res) signatures on W...

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Autors principals: Owen, Jonathan P., Rees, Helen C., Maddison, Ben C., Terry, Linda A., Thorne, Leigh, Jackman, Roy, Whitelam, Garry C., Gough, Kevin C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045483/
https://ncbi.nlm.nih.gov/pubmed/17652380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00640-07
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