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Molecular Profiling of Ovine Prion Diseases by Using Thermolysin-Resistant PrP(Sc) and Endogenous C2 PrP Fragments
Disease-associated PrP fragments produced upon in vitro or in vivo proteolysis can provide significant insight into the causal strain of prion disease. Here we describe a novel molecular strain typing assay that used thermolysin digestion of caudal medulla samples to produce PrP(res) signatures on W...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2045483/ https://ncbi.nlm.nih.gov/pubmed/17652380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00640-07 |
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